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Bi-CD47-IT was highly effective in two NSCLC PDX models. (A-C) NSCLC PDX1 (CT257-F4) mouse model. (A) Tumor volume on day 15 (pre-treatment), 25 (post treatment) and 44 (study endpoint). (B) Tumor size on day 44. (C) Tumor weight on day 44. (D-F) NSCLC PDX2 (220900-M3) mouse model. (D) Tumor volume on day 12 (pre-treatment), 22 (post treatment), 30 and 35 (study endpoint). (E) Tumor size on day 35. (F) Tumor weight on day 35. The p values in panel (A), (C), (D) and (F) were calculated using two-tailed Student t-test (GraphPad Prism 10).

Journal: bioRxiv

Article Title: Bivalent CD47 Immunotoxin for Targeted Therapy of Lung Cancer

doi: 10.64898/2025.12.24.696420

Figure Lengend Snippet: Bi-CD47-IT was highly effective in two NSCLC PDX models. (A-C) NSCLC PDX1 (CT257-F4) mouse model. (A) Tumor volume on day 15 (pre-treatment), 25 (post treatment) and 44 (study endpoint). (B) Tumor size on day 44. (C) Tumor weight on day 44. (D-F) NSCLC PDX2 (220900-M3) mouse model. (D) Tumor volume on day 12 (pre-treatment), 22 (post treatment), 30 and 35 (study endpoint). (E) Tumor size on day 35. (F) Tumor weight on day 35. The p values in panel (A), (C), (D) and (F) were calculated using two-tailed Student t-test (GraphPad Prism 10).

Article Snippet: 8) Human NSCLC PDX2 (220900-M3) NSG mouse model . NSG mice (7-8 weeks old from The Jackson Laboratory) were used for this study.

Techniques: Two Tailed Test

Bi-CD47-IT was highly effective in two NSCLC PDX models. (A-C) NSCLC PDX1 (CT257-F4) mouse model. (A) Tumor volume on day 15 (pre-treatment), 25 (post treatment) and 44 (study endpoint). (B) Tumor size on day 44. (C) Tumor weight on day 44. (D-F) NSCLC PDX2 (220900-M3) mouse model. (D) Tumor volume on day 12 (pre-treatment), 22 (post treatment), 30 and 35 (study endpoint). (E) Tumor size on day 35. (F) Tumor weight on day 35. The p values in panel (A), (C), (D) and (F) were calculated using two-tailed Student t-test (GraphPad Prism 10).

Journal: bioRxiv

Article Title: Bivalent CD47 Immunotoxin for Targeted Therapy of Lung Cancer

doi: 10.64898/2025.12.24.696420

Figure Lengend Snippet: Bi-CD47-IT was highly effective in two NSCLC PDX models. (A-C) NSCLC PDX1 (CT257-F4) mouse model. (A) Tumor volume on day 15 (pre-treatment), 25 (post treatment) and 44 (study endpoint). (B) Tumor size on day 44. (C) Tumor weight on day 44. (D-F) NSCLC PDX2 (220900-M3) mouse model. (D) Tumor volume on day 12 (pre-treatment), 22 (post treatment), 30 and 35 (study endpoint). (E) Tumor size on day 35. (F) Tumor weight on day 35. The p values in panel (A), (C), (D) and (F) were calculated using two-tailed Student t-test (GraphPad Prism 10).

Article Snippet: 7) Human NSCLC PDX1 (CT257-F4) NSG mouse model . NSG mice (7-8 weeks old from The Jackson Laboratory) were used for this study.

Techniques: Two Tailed Test